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Abstract
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Identifying genetic factors that influence susceptibility to CKD in patients with T2DM is essential for improving early risk stratification and preventive strategies. UMOD polymorphisms may serve as clinically relevant genetic markers for predicting renal and hypertensive complications in diabetic individuals. Understanding their role could facilitate personalized therapeutic approaches, optimize blood pressure management, and improve long-term renal outcomes. Furthermore, generating population-specific genetic data is crucial for translating genomic findings into clinical practice. This study addresses an important knowledge gap by evaluating UMOD variants in a Middle Eastern diabetic population, thereby enhancing the generalizability and clinical applicability of existing genetic evidence.
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