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Keywords
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Flow injection analysis, Insulin sensor, Cobalt hydroxide, Carbon ceramic, Electrocatalysis
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Abstract
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Cobalt hydroxide nanoparticles were prepared onto a carbon ceramic electrode (CHNjCCE) using the
cyclic voltammetry (CV) technique. The modified electrode was characterized by X-ray diffraction and
scanning electron microscopy. The results showed that CHN with a single-layer structure was uniformly
electrodeposited on the surface of CCE. The electrocatalytic activity of the modified electrode toward the
oxidation of insulin was studied by CV. CHNjCCE was also used in a homemade flow injection analysis
system for insulin determination. The limit of detection (signal/noise [S/N] ¼ 3) and sensitivity were
found to be 0.11 nM and 11.8 nA/nM, respectively. Moreover, the sensor was used for detection of insulin
in human serum samples. This sensor showed attractive properties such as high stability, reproducibility,
and high selectivity.
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