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Title
Flow injection amperometric detection of insulin at cobalt hydroxide nanoparticles modified carbon ceramic electrode
Type of Research Article
Keywords
Flow injection analysis, Insulin sensor, Cobalt hydroxide, Carbon ceramic, Electrocatalysis
Abstract
Cobalt hydroxide nanoparticles were prepared onto a carbon ceramic electrode (CHNjCCE) using the cyclic voltammetry (CV) technique. The modified electrode was characterized by X-ray diffraction and scanning electron microscopy. The results showed that CHN with a single-layer structure was uniformly electrodeposited on the surface of CCE. The electrocatalytic activity of the modified electrode toward the oxidation of insulin was studied by CV. CHNjCCE was also used in a homemade flow injection analysis system for insulin determination. The limit of detection (signal/noise [S/N] ¼ 3) and sensitivity were found to be 0.11 nM and 11.8 nA/nM, respectively. Moreover, the sensor was used for detection of insulin in human serum samples. This sensor showed attractive properties such as high stability, reproducibility, and high selectivity.
Researchers Esmaeil Habibi (First Researcher)، Eskandar Omidinia (Second Researcher)، Hassan Heidari (Third Researcher)، Maryam Fazli (Fourth Researcher)