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Abstract
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Multi-component reactions (MCRs) represents set up of three or more reactants and convert
them into higher molecular weight compound in one-pot method.1
Dipyrazolo-1,4-dihydropyridines, owing to their pharmacological and biological
properties, have garnered particular attention in both synthetic and medicinal research.2 These
compounds and their derivatives show divers biological activity such as antimicrobial,
analgesic, anticancer, antileishmanial, antimetabolic, antihyperlipidemic and as
immunostimulant activities.3 Also appropriately substituted pyrazolo- and
dipyrazolopyridines as luminescent dyes were evaluated as light-emitting materials in
electroluminescent devices.4
Herein we report for the first time, a catalyst-free, four-component reaction of As part of
our continuing efforts on the development of new strategies for the synthesis of heterocyclic
compounds5, dimethyl acetylenedicarboxylate, hydrazine hydrate, aromatic aldehydes and
ammonium acetate in refluxing ethanol, for the synthesis of novel 3,5-dimethoxycarbonyl
substituted dipyrazolo[3,4-b:4´,3´-e]pyridines (Scheme 1). The structure of synthesized
compounds was confirmed by spectroscopic methods.
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