مشخصات پژوهش

Multi-component reactions (MCRs) represents set up of three or more reactants and convert them into higher molecular weight compound in one-pot method.1 Dipyrazolo-1,4-dihydropyridines, owing to their pharmacological and biological properties, have garnered particular attention in both synthetic and medicinal research.2 These compounds and their derivatives show divers biological activity such as antimicrobial, analgesic, anticancer, antileishmanial, antimetabolic, antihyperlipidemic and as immunostimulant activities.3 Also appropriately substituted pyrazolo- and dipyrazolopyridines as luminescent dyes were evaluated as light-emitting materials in electroluminescent devices.4 Herein we report for the first time, a catalyst-free, four-component reaction of As part of our continuing efforts on the development of new strategies for the synthesis of heterocyclic compounds5, dimethyl acetylenedicarboxylate, hydrazine hydrate, aromatic aldehydes and ammonium acetate in refluxing ethanol, for the synthesis of novel 3,5-dimethoxycarbonyl substituted dipyrazolo[3,4-b:4´,3´-e]pyridines (Scheme 1). The structure of synthesized compounds was confirmed by spectroscopic methods.