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Keywords
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Carbonic source, Micro‐organisms, repressor pathway, signalling process, yeast.
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Abstract
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Glucose is not only a proper carbonic source for growing and sprouting of Saccharomyces cerevisiae, it
also functions as a molecule signalling for regulating physiological operations of the yeast. Yeast cells
exploit a variety of mechanisms in order to control glucose levels in their habitats for which they are
responsible and provide quick responses in relation to the available glucose changes in the
environment. The glucose signalling pathways are cAMP/PKA (consisting of Ras and the model
Gpr1/Gpa2), Rgt2/Snf3‐Rgt1 and the main repressor pathway containing Snf1. The pathway of
cAMP/PKA, shows an outstanding role in response to the changes of available glucose and the
initiation of signalling processes, is also responsible for the growth induction and meiosis.
Rgt2/Snf3‐Rgt1 has a significant role in the regulation of gene expression required for glucose
uptaking. Snf1, at first rate, is essential for the adaptation of yeast cells to the glucose limitation and
the growth in the substitute carbonic source, and second for the cellular responses to different
environmental tensions. In the present paper, the pathways involved in glucose‐sensing and signalling
mechanisms are reviewed.
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