مشخصات پژوهش

Glucose is not only a proper carbonic source for growing and sprouting of Saccharomyces cerevisiae, it also functions as a molecule signalling for regulating physiological operations of the yeast. Yeast cells exploit a variety of mechanisms in order to control glucose levels in their habitats for which they are responsible and provide quick responses in relation to the available glucose changes in the environment. The glucose signalling pathways are cAMP/PKA (consisting of Ras and the model Gpr1/Gpa2), Rgt2/Snf3‐Rgt1 and the main repressor pathway containing Snf1. The pathway of cAMP/PKA, shows an outstanding role in response to the changes of available glucose and the initiation of signalling processes, is also responsible for the growth induction and meiosis. Rgt2/Snf3‐Rgt1 has a significant role in the regulation of gene expression required for glucose uptaking. Snf1, at first rate, is essential for the adaptation of yeast cells to the glucose limitation and the growth in the substitute carbonic source, and second for the cellular responses to different environmental tensions. In the present paper, the pathways involved in glucose‐sensing and signalling mechanisms are reviewed.