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Abstract
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Solid phase extraction (SPE) is a routine extraction method for determining trace level
contaminants in environmental and biological samples. A new procedure for SPE, based on
the use of magnetic or magnetically modified adsorbents called magnetic solid-phase
extraction (MSPE). It adopts magnetic particles as adsorbents, which endow some unique
features in extraction and solve some problems associated with ordinary SPE.
In this study, Fe3O4 magnetic nanoparticles (MNPs) were synthesized by a simple
chemical co-precipitation method [1]. Fe3O4MNPs were then modified by carbon via a
hydrothermal method by reaction between glucose and Fe3O4MNPs [1]. Fe3O4MNPs and
carbon coated Fe3O4 (C/Fe3O4) MNPs were characterized by different methods such as field
emission scanning electron microscopy, Fourier transform infrared, X-ray power diffraction,
etc. The prepared C/Fe3O4 MNPs were employed for MSPE of amlodipine, losartan, and
carvedilol. After extraction the drugs were determined by high performance liquid
chromatography with ultraviolet detection (HPLC–UV). Several factors influencing on the
extraction efficiency of drugs such as pH, adsorbent amount, ionic strength, and extraction
time were optimized by multivariate optimization. Under the optimal MSPE conditions the
analytical performance such as limits of detection, limits of quantification, relative standard
deviations, dynamic linear ranges, enrichment factors, etc. have been calculated.
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