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Keywords
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Drug delivery, Controlled drug release, Drug nanocarriers, Graphene quantum
dots, Methotrexate
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Abstract
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The advanced drug delivery systems, combining the ability to improve the therapeutic
efficacy and to reduce side effects of drugs represent a challenge for medicine.
Nanotechnology offers a wide range of new strategies to produce innovative nanomaterials,
suitable for the development of a large number of smart drug delivery systems, ranging from
carbon based nanomaterials (CBNs) toward metallic nanoparticles and nanobiocomposites
(NBCs) materials. Among all nanostructures, carbon based nanomaterials seem to be eligible
as nanovector of drugs and therapeutics. Graphene exhibits ananosheet structure that makes
easier the translocation of the nanocarrier across the cellular membranes and the cellular
compartments. Graphene and graphene derivatives exhibit excellent antibacterial and
antimicrobial properties, fundamental aspect to avoid/to minimize the bacterial and microbial
infections that could occur during therapeutics deliveries [1]. Drug delivery systems are
essential components of drugs controlled release [2]. In this articel, the application of
graphene quantum dot nanocomposite (GQD)/Cu-Ni coated with magnetic iron oxide
nanoparticles was investigated and the synthesized nanocomposite was evaluated as a
nanocarrier of the anti-cancer drug methotrexate.
Keywords:
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