مشخصات پژوهش

The advanced drug delivery systems, combining the ability to improve the therapeutic efficacy and to reduce side effects of drugs represent a challenge for medicine. Nanotechnology offers a wide range of new strategies to produce innovative nanomaterials, suitable for the development of a large number of smart drug delivery systems, ranging from carbon based nanomaterials (CBNs) toward metallic nanoparticles and nanobiocomposites (NBCs) materials. Among all nanostructures, carbon based nanomaterials seem to be eligible as nanovector of drugs and therapeutics. Graphene exhibits ananosheet structure that makes easier the translocation of the nanocarrier across the cellular membranes and the cellular compartments. Graphene and graphene derivatives exhibit excellent antibacterial and antimicrobial properties, fundamental aspect to avoid/to minimize the bacterial and microbial infections that could occur during therapeutics deliveries [1]. Drug delivery systems are essential components of drugs controlled release [2]. In this articel, the application of graphene quantum dot nanocomposite (GQD)/Cu-Ni coated with magnetic iron oxide nanoparticles was investigated and the synthesized nanocomposite was evaluated as a nanocarrier of the anti-cancer drug methotrexate. Keywords: