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Abstract
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The genus Artemisia is one of the largest and varied genera of the Asteraceae family.
The Artemisia species have many medicinal properties that are used to treat a variety of
diseases, including: antihypertensive, invigorating bloodcirculation, antiallergy,
antimalarial, antiviral, antitumor and antioxidant. Artemisia deserti Krasch is one of the
Artemisia species that is a Chinese traditional medicinal herb [1, 2]. The purpose of the
existent study was to investigate the cytotoxic activity of different extracts including nhexane,
chloroform, ethyl acetate, acetone, methanol, methanol/water extracts from
aerial parts of A. deserti against in vitro ovarian cancer cell line (OVCAR-3). The
cytotoxic activity of extracts was evaluated by MTT (3-[4,5-dimethylthiazol-2yl]-2,5diphenyl
tetrazolium bromide) assay on the ovarian cell membrane within 48 hours at
different concentrations. The IC
50
values of n-hexane, chloroform, ethyl acetate, acetone,
methanol, and methanol/water extracts were calculated (11.01, 8.444, 58.29, 144.4,
>1000, 31.35 µg/mL respectively). The chloroform and n-hexane extracts indicated the
highest cytotoxic activity on the OVCAR-3 cell line among the other extracts. According
to the calculated values, methanol extracts has the lowest cytotoxic activity against
OVCAR-3. The present study revealed that A. deserti chloroform extract might have a
high potential to use as an anti-cancer drug.
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