مشخصات پژوهش

The genus Artemisia is one of the largest and varied genera of the Asteraceae family. The Artemisia species have many medicinal properties that are used to treat a variety of diseases, including: antihypertensive, invigorating bloodcirculation, antiallergy, antimalarial, antiviral, antitumor and antioxidant. Artemisia deserti Krasch is one of the Artemisia species that is a Chinese traditional medicinal herb [1, 2]. The purpose of the existent study was to investigate the cytotoxic activity of different extracts including nhexane, chloroform, ethyl acetate, acetone, methanol, methanol/water extracts from aerial parts of A. deserti against in vitro ovarian cancer cell line (OVCAR-3). The cytotoxic activity of extracts was evaluated by MTT (3-[4,5-dimethylthiazol-2yl]-2,5diphenyl tetrazolium bromide) assay on the ovarian cell membrane within 48 hours at different concentrations. The IC 50 values of n-hexane, chloroform, ethyl acetate, acetone, methanol, and methanol/water extracts were calculated (11.01, 8.444, 58.29, 144.4, >1000, 31.35 µg/mL respectively). The chloroform and n-hexane extracts indicated the highest cytotoxic activity on the OVCAR-3 cell line among the other extracts. According to the calculated values, methanol extracts has the lowest cytotoxic activity against OVCAR-3. The present study revealed that A. deserti chloroform extract might have a high potential to use as an anti-cancer drug.