مشخصات پژوهش

New pH sensitive Polymer–Clay nanocomposites were prepared via In-situ copolymerization of methacrylic acid with modified Laponite (LAP). Firstly an ionic liquid monomer, 1-(4-vinylbenzyl)-3-methylimidazoliumchloride, was synthesized through the quaternization of N-methylimidazole with 4-vinylbenzylchloride. Then, the ionic liquid monomer was intercalated between the LAP Layers by the ion-exchange reaction and subsequently copolymerized with methacrylic acid. The composites were characterized by FT-IR, XRD, TGA, EDX and SEM to study their structure and the role, LAP plays. Naproxen, was entrapped into these pH-sensitive nano-carriers and the in vitro release profiles were established separately in both enzyme-free simulated gastric and colonic fluids (SGF) and (SCF).