مشخصات پژوهش

In this study, simple, effective, and general processes were used for the synthesis of a new nano-molecularly imprinted polymers (MIPs) layer on magnetic Fe3O4 NPs with uniform coreshell structure by combining surface imprinting and nanotechniques. The first step for synthesis of the magnetic NPs was co-precipitation of Fe2+ and Fe3+ in an ammonia solution. Then, an SiO2 shell was coated on the magnetic core with the Stöber method. Subsequently, the C=C groups were grated onto the silica-modified Fe3O4 surface by 3-(Trimethoxysilyl) propyl methacrylate. Finally, the MIPs films were formed on the surface of Fe3O4@SiO2 by the copolymerization of C=C end groups with meth acrylic acid (the functional monomer), ethylene glycol dimethacrylate (the cross-linker), 2, 2-azobisisobutyronitrile (the initiator), and tizanidine (the template molecule). The products were characterized using techniques that included Fourier transform infrared (FT-IR) spectroscopy, x-ray diffraction (XRD), thermo gravimetric analysis (TGA), scanning electron microscopy (SEM), UVspectrophotometry, transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). Measurement of tizanidine through use of the core-shell magnetic molecularly imprinted polymers nanoparticles (MMIPs- NPs) in human plasma samples compared to the paracetamol showed, synthesized nano-sized MMIP for tizanidine has acted selectively.