مشخصات پژوهش

Imipramine, trimipramine and desipramine are active ingredients of psychiatric drugs widely used in thetreatment of depressive disorders.These tricyclic antidepressantsare used primarily in the clinical treatment ofmood disorders such as major depressive disorder, dysthymia,and bipolar disorder, especially of the treatment-resistant variants.However, their overdose is fatal to the central nervoussystem and may result in drowsiness, convulsions, respiratorydisorders, ophthalmoplegia and finally coma. Hence, theirdetermination in pharmaceutical formulations, urine andblood serum is of tremendous importance [1]. In more recent years, magnetic nanoparticles (MNPs) have beenstudied for biomedical and biotechnological applications. For many of these applications, surface modificationof MNPs is a key challenge and can be accomplished by molecularly imprinted polymer (MIP) [2]. MIPs are artificial polymerswhich are formed in the presence of a target molecule that finallyis removed by the proper solvents; therefore, the obtained specificcavities are complement to the target molecule in shape, size andfunctional groups[3]. The conventional method for the preparation of MIPs is bulkpolymerization, which is traditional and exhibit high selectivity.There are some defects for this polymerization method suchas: imperfect removal of template molecules, slow mass transferof template molecules from the polymer backbone, heterogeneousdistribution of the binding sites, poor site accessibility and smallbinding capacity in some cases. Therefore, surface polymerizationhas been suggested for the improving of accessibility to the targetmolecules, more suitable mass transfer and complete removalof templates. In this regard, the surface grafting MIPs havebeen developed on the different surfaces [3] In this work, we performed the combination of imprinting polymersand MNPs for selective and effective recognition of imipramine from different samples. The MNPs were modified by vinyl groups andthe