مشخصات پژوهش

صفحه نخست /Scaffolding polymeric ...
عنوان
Scaffolding polymeric biomaterials: Are naturally occurring biological macromolecules more appropriate for tissue engineering?
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
polymeric biomaterials
چکیده
worldwide. Current treatments have limitations including, low graft efficiency, shortage of donor organs, as well as immunological problems. In this context, tissue engineering (TE) was introduced as a novel and versatile approach for restoring tissue/organ function using living cells, scaffold and bioactive (macro-)molecules. Among these, scaffold as a three-dimensional (3D) support material, provide physical and chemical cues for seeding cells and has an essential role in cell missions. Among the wide verity of scaffolding materials, natural or synthetic biopolymers are the most commonly biomaterials mainly due to their unique physicochemical and biological features. In this context, naturally occurring biological macromolecules are particular of interest owing to their low immunogenicity, excellent biocompatibility and cytocompatibility, as well as antigenicity that qualified them as popular choices for scaffolding applications. In this review, we highlighted the potentials of natural and synthetic polymers as scaffolding materials. The properties, advantages, and disadvantages of both polymer types as well as the current status, challenges, and recent progresses regarding the application of them as scaffolding biomaterials are also discussed.
پژوهشگران مجتبی عباسیان (نفر اول)، بخشعلی معصومی (نفر دوم)، رحیم محمدرضائی (نفر سوم)، هادی صمدیان (نفر چهارم)، مهدی جایمند (نفر پنجم)