مشخصات پژوهش

Cancer is one of the leading causes of death in the world. Cancer is caused by the uncontrolled growth of cells. Breast cancer is the third most common cancer in the world. Chemotherapy, radiation therapy, surgery, etc. are common methods for treating cancer. In these methods, in addition to cancer cells, healthy cells are also damaged. For this reason, they are looking for methods that purposefully transfer anticancer agents to cancer cells. For this reason, the targeted drug delivery in nano scale for treatment of cancer is examined [1,2]. In this study, chitosan nanoparticles were synthesized by ionic gelation method. To improve the synthesis and effective entrapment of curcumin (anti-cancer compound), the role of several factors including chitosan concentration, chitosan to TPP linker ratio and drug concentration were investigated [3]. Using spectrophotometric technique, FTIR analysis and electron microscopy (SEM), the fabrication of nanoparticles and the entrapment of curcumin in nanoparticles were confirmed. The results also showed that the highest rate of curcumin trapping occurs in the chitosan bed with one percent. The effect of using detergents such as Tween 80 had an adverse effects on the entrapment of curcumin in the nanoparticle, so that in the absence of Tween 80, maximum entrapment was observed, which is probably due to the severe hydrophobic properties of curcumin. Among the different ratios of chitosan to TPP, a ratio of 2 to 1 was the best for making nanoparticles and trapping curcumin. Also, chitosan nanoparticles showed better release of curcumin at pH and physiological temperatures in this ratio. At high and low concentrations of the TPP linker, the nanoparticle structure probably does not have the desired cross-linking to curcumin entrapment and its release [4].