مشخصات پژوهش

The escalating global rates of MRSA infections underscore the critical need for innovative therapeutic approaches. The mecA gene, which confers resistance by producing PBP2a, is a key target for understanding and combating MRSA. Resistance mechanisms are complex, involving not only the mecA gene but also auxiliary genes such as femA and femB, which play crucial roles in the resistance phenotype by stabilizing cell wall synthesis. Research into these auxiliary genes is vital for developing new therapeutic interventions. Understanding how these genes contribute to resistance will aid in the design of more effective treatments and diagnostic tools. Silver nanoparticles represent a novel approach to addressing MRSA’s antibiotic resistance. These nanoparticles have been shown to disrupt bacterial cell walls and potentially affect gene expression, offering a promising adjunct to traditional antibiotics. Studies suggest that silver nanoparticles can penetrate bacterial cell walls and interfere with essential cellular processes, which may restore the effectiveness of older antibiotics that MRSA has developed resistance to.