مشخصات پژوهش

New biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5- ammino-2-hydroxybenzoic acid (5-ASA) in the main chain were prepared by terpolymerization of methacrylic acid; (MA), 2-hydroxyethylmethacrylate (HEMA), and bis (trimethylsilyloxy) methylsilane (VBM) in the presence of some new cross-linking agents. The monomers and polymers were characterized by FT-IR and 1H-NMR spectroscopy, and studied by DSC analysis. The hydrolysis of them was carried out in cellophane membrane dialysis bags containing aqueous buffer solution at 37ºC. Detection of the hydrolysis product by UV spectroscopy showed that attaching of siloxane units in these hydrogels modified this drug delivery system.