مشخصات پژوهش

Dihydropyrimidinones (DHPMs), an important class of organic compounds, have become increasingly significant due to their therapeutic and pharmacological properties. Biginelli-type condensation reaction, which is one of the multi-component reactions (MCRs), is a very useful reaction for preparing 3,4-dihydropyrimidin-2(1H)-ones, their thiones analogs and other related heterocyclic compounds [1]. With the growing awareness of environmental issues and increasing need to reduce use of harmful chemicals in chemical, medicinal and industrial research in view of their effects, and the consequent risk for the human health, in recent years green chemistry has been a fascinating area of chemical research. The green chemistry aims to design environmentally benign chemical processes and synthetic methodologies in order to eliminate or reduce the use of hazardous and toxic chemicals at any stage of production in the industry or laboratory [2]. Within the framework of green chemistry, solvents occupy a strategic place. Green chemistry aims to replace the hazardous and/or harmful solvents with more environmentally friendly. A recent alternative solvent is the category of Deep Eutectic Solvents (DESs). Deep eutectic solvents, also known as deep eutectic ionic liquids (DEILs) or low-melting mixtures (LMMs) or low transition temperature mixtures (LTTMs) in the literature, have become more and more attractive in recent years due to their interesting properties and benefits, such as low cost of components, easy to prepare, tunable physicochemical properties, negligible vapor pressure, non-toxicity and biodegradability. These eutectic mixtures have been widely used as green and sustainable media as well as catalysts in many chemical processes [3]. Herein, we wish to report the utilization of novel ChCl:TFA deep eutectic solvent in the one-pot, three-component Biginelli reaction.