مشخصات پژوهش

The aim of this article was to investigation the function of silica based polycrystalline that modified with ZnO and CaF2 and doped with 6% Fe3O4. The human pulp stem cells cultured in the presence of samples. The effects of heating-induced crystallization on the glass structure were studied by DSC and X-ray diffraction. The particle size of prepared samples was studied by TEM analysis. The bioactivity of samples were analyzed by apatite-formation ability in DMEM solution through SEM-EDX, biocompatibility was evaluated through the SHEDs cells proliferation, adhesion and spreading on surface of samples by MTT assay and ALP activity assay. Optical and SEM images displayed that co-operation of ZnO and CaF2 led to appropriate circumstance for cells proliferation, adhesion and spreading. Proliferation of pulp stem cells after 7 days of incubation in culture media containing ZC8, FC8 and ZFC4 yielded values 0.3, 1.7 and 2.8 in comparison with control , respectively.