مشخصات پژوهش

Molecularly imprinted polymers (MIP) have attracted much attention in pharmaceutical fields due to their distinct advantages. In recent years, it has been found that these MIP-based drug delivery systems (MIP-DDS) can improve the therapeutic efficacy of the drugs as a new strategy for delivering therapeutic agents with desired controlled release and/or targeting efficiency. When MIP are used as the carriers, sustained drug release can be achieved due to the specific selectivity and affinity of MIP to template molecules, which make MIP to be a promising drug delivery system [1, 2]. An intelligent MIP-DDS can be obtained by employing functional materials, including magnetic, pH sensitive, temperature sensitive, photo sensitive and bio-macromolecule sensitive materials. Graphene quantum dots (GQDs), a monoatomic thickness structure similar to that of graphene, have unique optical properties and retain many of the electrical and mechanical properties of graphene, have many applications in bioimaging and drug delivery [3]. In this regard, the aim of this study was to preparation of a chitosan-based molecular imprinted polymer for anticancer drug using the sol-gel method. Also, graphene quantum dot (GQD) was prepared by the pyrolysis of citric acid (CA), and was incorporated into chitosan through electrostatic interactions and H-bonding. The nonimprinted polymer (NIP) was prepared and used as a control, during the whole experiment. The physicochemical and morphological characteristics of the prepared sytems were investigated using FTIR, XRD, TGA and SEM analyses. Afterwards, the performance of product as an anti-cancer carrier was examined through in-vitro drug relaeses experiments. Results showed the influence of GQDs content on the system property. The specificity of the prepared system into drug was indicated by an acceptable imprinting factor. From the in vitro drug release studies, the prepared MIP system exhibited an excellent controlled drug release profile without