مشخصات پژوهش

صفحه نخست /Robust adhesive nanocomposite ...
عنوان
Robust adhesive nanocomposite sponge composed of citric acid and nano clays modified cellulose for rapid hemostasis of lethal non-compressible hemorrhage
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Rapid hemostasis Tissue adhesive sponge Modified cellulose Polydopamine Laponite Intrinsic hemostasis pathway Non-compressible hemorrhage
چکیده
Massive bleeding control plays the main role in saving people's lives in emergency situations. Herein, modified cellulose-based nanocomposite sponges by polydopamine (PDA) and laponite nano-clay was developed to sturdily deal with non-compressible lethal severe bleeding. PDA accomplishes supreme adhesion in the bleeding site (∼405 kPa) to form strong physical barrier and seal the position. Sponges super porous (∼70 % porosity) and super absorbent capacity (48 g blood absorbed per 1 g sponge) by concentrating the blood cells and platelets provides the requirements for primary hemostasis. Synergistically, the nanocomposite sponges' intelligent chemical structure induces hemostasis by activation of the XI, IX, X, II and FVII factors of intrinsic and extrinsic coagulation pathways. Excellent hemostatic performance of sponges in-vitro was assessed by RBC accumulation (∼100 %), blood clotting index (∼10 %), platelet aggregation/activation (∼93 %) and clotting time. The nanocomposite sponges depicted super performance in the fatal high-pressure non-compressible hemorrhage model by reducing of >2, 15 and 3 times in the bleeding amount at New Zealand rabbit's heart and liver, and rat's femoral artery bleeding models, respectively compared to commercial hemostatic agents (Pvalue˂0.001). The in-vivo host response results exhibited biosafety with no systemic and significant local inflammatory response by hematological, pathological and biochemical parameters assessments.
پژوهشگران احمد محمودزاده (نفر اول)، نسرین ولی زاده (نفر دوم)، مهدی عدالتی (نفر سوم)، منیره خردادمهر (نفر چهارم)، زیبا ذاکری گرگری (نفر پنجم)، رویا صالحی (نفر ششم به بعد)، سید حسین جارالمسجد (نفر ششم به بعد)