مشخصات پژوهش

The synthesis of lidocaine derivatives is of significant interest due to their biological and medicinal activities. Adamantane, a hydrocarbon with affinity for lipid bilayers, is used to enhance pharmacokinetic and pharmacodynamic properties in drug development . It serves as a building block for functional groups or as part of self-aggregating systems like liposomes. Diamondoids, including adamantane, are carbon cage molecules found in petroleum, used for their structural similarity to diamond. Incorporating adamantane into drugs often improves pharmacological properties without increasing toxicity, leading to promising drug candidates. Thus, synthesizing novel lidocaine with an adamantane moiety is pursued for enhanced biological activity .