مشخصات پژوهش

Introduction: MDM4, a negative regulator of p53 tumor suppression pathway, has been demonstrated to be overexpressed in a variety of human cancers. Different researches have revealed that the rs4245739A>C polymorphism of MDM4 in 3¢-untranslated region makes it a miR-191 target site which leads to lower MDM4 expression. This study aimed to detect if rs4245739 single nucleotide polymorphism (SNP) of MDM4 gene impresses the thyroid cancer development in Iranian-Azeri women. Methods: Blood samples were taken from 232 healthy controls and 130 patients with thyroid cancer and ethnicity of Iranian-Azeri. In order to genotype, Tetra-ARMS PCR was exerted. SPSS for Windows (version 22.0, IBM SPSS Inc., USA) and the SHEsis online software were used for data analysis. Results:Data analysis demonstrated that alleles of MDM4 rs4245739 SNP had no significant different frequencies between patients and controls (P>0.05). Additionally, genotypes of MDM4 rs4245739 SNP could not increase or decrease breast cancer risk in patients compared to healthy subjects. Conclusions: Considering the lack of association between MDM4 rs4245739 polymorphism and thyroid cancer, rs4245739 polymorphism of this gene seems to have no significant role in the pathophysiology of the disease.