مشخصات پژوهش

صفحه نخست /Synthesis, identification and ...
عنوان
Synthesis, identification and in vitro drug release of layered zinc hydroxide-gemifloxacin nanohybrids
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Synthesis  Gemifloxacin  Layered zinc hydroxide  Nanohybrid
چکیده
The intercalation of fluoroquinolone antibiotic, Gemifloxacin (GEM) anions, into layered zinc hydroxide (LZH) has been achieved by using ion-exchange method. The GEM-LZH/Chitosan nanocomposite coating Chitosan nanocomposite was prepared in alkaline aqueous solution. Powder X-ray diffraction studies confirmed a basal spacing of 25.54 A ° , showing that the GEM was successfully intercalated into the LZH interlayer. The arrangement of GEM anions was in a monolayer form between the LZH interlayers. Fourier transform infrared spectroscopy results exhibited the formation of the host–guest nanohybrid without any change in the structure of the GEM. The increased thermal stability of nanohybrid was confirmed by thermal analyses. The in vitro release study of GEM from nanohybrid and nanocomposite was investigated in phosphate buffer saline solution of pH 4.8 and 7.4 using ultraviolet–Visible spectroscopy.
پژوهشگران حافظه نبی پور (نفر اول)، مؤید حسینی صدر (نفر دوم)، بهزاد سلطانی دهخوارقانی (نفر سوم)