مشخصات پژوهش

The intercalation of amoxicillin trihydrate (AMOX) into layered zinc hydroxide (LZH) has been achieved via ion-exchange method. The resulted nanocomposite (AMOX-LZH) has been thoroughly characterised by a number of techniques including powder X-ray diffraction (PXRD), FT-IR spectroscopy, TGA/DTG analysis and scanning electron microscopy (SEM). The PXRD results showed that the gallery height of LZH was expanded from 9.57 to 11.97 A
, indicating that the AMOX anions were successfully intercalated into the interlayer space of LZHs. The increased thermal stability of nanocomposite was confirmed by TGA/ DTG analyses. Improved antibacterial activity and minimum inhibitory concentration of AMOX-LZH nanocomposite was evaluated against Grampositive bacteria Staphylococcus aureus, Klebsiella pneumonia and Gram- negative Escherichia coli using the disk diffusion technique. The sustained release of amoxicillin drug from the AMOX-LZH nanocomposite was also verified.