مشخصات پژوهش

The objective of this study is to utilize the pH sensitivity of modified mesoporous silica nanoparticles (MSN) for oral drug delivery. In the first time, a pH-sensitive ionic liquid was synthesized through the quaternization of 3-aminopropyltrimethoxysilane (3-ATMS) with sodium monochloroacetate (SMCA). Then, silica nanoparticle was modified by this pH-sensitive ionic liquid and converted to a pH-sensitive positive-charge silica nanoparticle (PCSN). The nanoparticle was characterized by FTIR and SEM. Naproxen as anionic drug molecules was entrapped in this pH-sensitive positive-charge silica nanoparticles (PCSN) and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4).