مشخصات پژوهش

Identification of master regulatory genes is one of the main challenges in biology. They are important in controlling other genes in a gene regulatory network. In this paper, we consider weighted gene regulatory network (WGRN) problem which aims to determine a set of master regulator genes with minimum cardinality and maximum weight. We reformulate this problem as a multiobjective programming model based on the Minimum Dominating Set (MDS) model for directed graphs. This method is applied on a simple network.