مشخصات پژوهش

The main objective of this work was chemically bioactivation of the conducting polyanizidine (PANIZ) by incorporating a polyester such as polycaprolactone (PCL). Modified PANIZ nanocomposites were synthesized through ring opening and chemical oxidation polymerizations. A four-point probe was applied to measure the conductivity of newly synthesized star-like block copolymer (S-PCL-PANIZ) nanocomposite, which was about 0.44 S cm-1. Conductive biodegradable nanofibers were prepared by electrospinning with 25 and 75 % (wt/wt) S-PCL-PANIZ to PCL. The contact angle of each prepared nanofiber was 87±3 o, supporting their usefulness for cell culture. The cultured mouse osteoblast MG63 cells demonstrated normal morphology and significantly higher adhesion and spreading on the nanofiber. The bioactivated PANIZ based nanocomposite may be fruitful in tissue engineering to fabricate conducting biodegradable scaffolds with improved cell adhesion properties for various cell cultures.