مشخصات پژوهش

صفحه نخست /Association of Omentin-1 with ...
عنوان
Association of Omentin-1 with Oxidative Stress and Clinical Significances in Patients with Breast Cancer
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Breast neoplasms • Omentin-1 Clinical Antioxidant Prognosis Gene expression
چکیده
Abstract Purpose: Breast cancer (BC) is globally the main reason of cancer-related deaths in women. Omentin-1, an anti-inflammatory and antioxidant adipokine, plays different roles in tumorigenesis and anti-oncogenic pathways. In present study, we investigated the association of omentin-1 with oxidative stress and clinical significances in healthy controls and BC patients to assess the prognostic and diagnostic value of omentin-1 in this cancer. Methods: This case-control study included 88 BC patients and 86 healthy controls. The serum levels of omentin-1 were assessed by enzyme-linked immunosorbent assays methods. Also, total antioxidant capacity (TAC), total oxidant status (TOS) and malondialdehyde (MDA) serum levels were measured by spectrophotometer. quantitative real-time polymerase chain reaction (qRT-PCR) was applied to the measurement of gene expression of omentin-1. Results: the serum levels of omentin-1 were significantly lower in the BC patients compared to the healthy controls (P < 0.001). Moreover, gene expression of omentin-1was significantly downregulated in the BC tissues compared to the adjacent normal tissues (P < 0.001). Gene expression of omentin-1and its serum levels were significantly higher in grade I compared with grade II and III (P = 0.001, P < 0.001, respectively). Additionally, the serum levels of omentin-1 in the p53-positive BC patients were significantly higher than the p53-negative BC patients (P = 0.001). There was an inverse correlation between the serum levels of MDA and TOS with the serum levels of omentin-1 (r=-0.436, r=-461, respectively). Conclusion: We conclude that omentin-1 may have a good prognostic and diagnostic roles in the BC patients and decreases oxidative stress in these patients.
پژوهشگران ناهیده طهماسبپور (نفر اول)، محمدعلی حسینپور فیضی (نفر دوم)، نسرین ضیامجیدی (نفر سوم)، ناصر پولادی (نفر چهارم)، وحید منتظری (نفر پنجم)، مریم فرهادیان (نفر ششم به بعد)، رقیه عباسعلیپورخبیر (نفر ششم به بعد)