مشخصات پژوهش

Since amphetamine-type stimulants (ATS) drugs have been approximately abused by 24.7 million people [1], there is a growing global demand for the selective trace amount measuring them in the biological fluids. Methamphetamine (MAMP) is one of the famous industrial opiates. Its excessive consumption disrupts the function of the brain neurotransmitters and increases heart rate, respiratory problems and even worse, may lead to stroke and death [2]. So, sensitive MAMP detection in the biological and street samples is vital for several organizations such as forensic medicine, anti-drug headquarters and diagnostic clinics. We fabricated a glassy carbon electrode (GCE) modified with nanodiamond-derived carbon nanoonions (CNOs) and silver nanodendrites (AgNDs), denoted as the AgNDs/CNOs/GCE, as the sensor for MAMP detection. The electron dispersive X–ray analyzer (EDX) and X-ray diffraction patterns (XRD) techniques confirmed the presence of the applied elements as the modifier on the surface. SEM images of the embedded sensing interface revealed a unique distribution of the dendritic structures similar to tree foliage on the GCE surface. The sensing interface presented a high surface area, more conductivity and excellent capability for MAMP catalysis compared to the bare GCE. MAMP was quantitatively detected under two broad concentration ranges from 99 nM to 7.48 μM and 7.48 μM to 59.88 μM with a limit of detection (LOD) of 30 nM. The sensor feasibility in MAMP monitoring was satisfactorily evaluated by analyzing some human blood serum and urine specimens.